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1 article(s) from Hegedüs, Rózsa

Comparative cell biological study of in vitro antitumor and antimetastatic activity on melanoma cells of GnRH-III-containing conjugates modified with short-chain fatty acids

Eszter Lajkó,
Sarah Spring,
Rózsa Hegedüs,
Beáta Biri-Kovács,
Sven Ingebrandt,
Gábor Mező and
László Kőhidai

Beilstein J. Org. Chem. 2018, 14, 2495–2509, doi:10.3762/bjoc.14.226

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Graphical Abstract

Figure 1: Schematic structure of Dau-conjugated GnRH-III or its derivatives containing ⁴Lys with acetyl or bu...

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Figure 2: Cellular uptake of Dau–GnRH-III conjugates and free daunorubicin (Dau) by A2058 cells. Cellular upt...

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Figure 3: Short-term growth inhibitory effects of the conjugates and daunorubicin (Dau) on A2058 cells. The m...

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Figure 4: Effects of conjugates and daunorubicin (Dau) on cell cycle progression of A2058 melanoma cells. The...

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Figure 5: Effects of the conjugates and daunorubicin (Dau) on melanoma cell adhesion. The Delta CI (Delta Cel...

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Figure 6: Chemotactic effects of Dau–GnRH-III conjugates on A2058 cell line. The ‘Chemotaxis index’ (Chtx. in...

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Figure 7: Effects of GnRH-III(Dau=Aoa) (a–c), [⁴Lys(Ac)]-GnRH-III(Dau=Aoa) (d–f) and [⁴Lys(Bu)]-GnRH-III(Dau=...

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Figure 8: Schematic representation of the proposed mechanisms of the effects of GnRH-III conjugates containin...

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Published 26 Sep 2018

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